Our lab developped a bioreactor system that enables studies of live cells inside the magnet with gentle perfusion to deliver cell medium with hyperpolarized xenon. Hyper-CEST allows identification of various xenon pools, both inra and extra cellular. Cells are embedded in alginate beads that allow biosensor uptake. Such sensors are bi-functional for fluorescence co-registration of labelled cells with confocal microscopy.
The fast imaging approaches designed at FMP allow clear MRI cell tracking with xenon biosensors.