Contact
Dr. Leif Schröder

phone +49 30 94793 121
🖂  lschroeder(at)fmp-berlin.de
Leibniz-
Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+49 30 94793 - 100
+49 30 94793 - 109 (Fax)
🖂  info(at)fmp-berlin.de
Intro | Members | Projects | Publications | Methods
Funding | News | Collaborations | Links | Teaching
Biosensor Engineering and Characterization
Molecular Imaging
Projects

Current Team Members

 

Cooperation Partners

 

Related Publications

Angew. Chem. Int. Ed. 54: 2806 (2015)

[doi: 10.1002/anie.201410573]

 

Bioconjugate Chem.  29(12): 4004 (2018)

[doi: 10.1021/acs.bioconjchem.8b00814]

 

Starting from cryptophane-A as a building block, we design different xenon biosensors. Contrary to our nanoparticular approach, these sensor protoptypes are small molecular probes that do not aggregate. Their xenon NMR signal is very sensitive to the environment and can report different physico-chemical events. Such sensors change their resonance frequency, e.g., upon cellular internalization or upon interaction with a specific protein. x
Properties of the xenon host can be changed by attaching different functional units to implement binding to specific targets. We optimize the synthesis for reducing unwanted side products, explore mechanisms for switchable sensors, and characterize the biochemical behaviour of these conjugates.

Attention Score

CrA-FAM