Dr. Leif Schröder
Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
13125 Berlin, Germany
+4930 94793 - 100
+4930 94793 - 109
phone +49 30 94793 121
Pairing the high xenon spin polarization achieved by LEIPNIX with fast MRI encoding schemes like EPI, our lab developped the first sub-second imaging scheme for low concentrations of xenon biosensors. The smash-CEST technique (i.e., shared magnetization after single hyperpolarization prior to CEST encoding) uses a signle xenon delivery and a variable flip angle (45° and 90°) to encode both the reference and the saturation transfer image.
It allowed the first time-resolved studies of diffusion-driven cryptophane uptake in a two-compartment phantom (see movie).
This work has been awarded with a 2012 Gorter award of the German Chapter of the International Society for Magnetic Resonance in Medicine. [More]