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Smash-CEST
Molecular Imaging
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Pairing the high xenon spin polarization achieved by LEIPNIX with fast MRI encoding schemes like EPI, our lab developped the first sub-second imaging scheme for low concentrations of xenon biosensors. The smash-CEST  technique (i.e., shared magnetization after single hyperpolarization prior to CEST encoding) uses a signle xenon delivery and a variable flip angle (45° and 90°) to encode both the reference and the saturation transfer image.
It allowed the first time-resolved studies of diffusion-driven cryptophane uptake in a two-compartment phantom (see movie).

This work has been awarded with a 2012 Gorter award of the German Chapter of the International Society for Magnetic Resonance in Medicine. [More]