Contact
Dr. Leif Schröder
phone +49 30 94793 121
🖂 lschroeder(at)fmp-berlin.de
phone +49 30 94793 121
🖂 lschroeder(at)fmp-berlin.de
Leibniz-
Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+49 30 94793 - 100
+49 30 94793 - 109 (Fax)
🖂 info(at)fmp-berlin.de
Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+49 30 94793 - 100
+49 30 94793 - 109 (Fax)
🖂 info(at)fmp-berlin.de
Intro | Members | Projects | Publications | Methods
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Funding | News | Collaborations | Links
Time-resolved CEST Spectroscopy
Molecular Imaging
Projects
Projects
Fast grandient-encoded CEST spectroscopy can be used to acquire a time-resolved series of CEST spectra. To illustrate the capabilities of this technique we studied the temperature-induced changes in the spectrum of a para-CEST agent.
Cooling or heating of a solution containing such an agent with the variable temperature unit (VTU) of an NMR spectrometer changes both the chemical shift position and the exchange rate of the resonance from coordinated water.
Plotting the chemical shift separation of the CEST and the bulk water peak versus time illustrates that it takes ca. 40 min for the temperature inside the sample to stabilize.
Cooling or heating of a solution containing such an agent with the variable temperature unit (VTU) of an NMR spectrometer changes both the chemical shift position and the exchange rate of the resonance from coordinated water.
Plotting the chemical shift separation of the CEST and the bulk water peak versus time illustrates that it takes ca. 40 min for the temperature inside the sample to stabilize.
