Contact
Dr. Leif Schröder
Leibniz-Institut für
Molekulare
Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100
+4930 94793 - 109
phone +49 30 94793 121
Starting from cryptophane-A as a building block, we design different xenon biosensors. Their xenon NMR signal is very sensitive to the environment and can report different physico-chemical events. Such sensors change their resonance frequency, e.g., upon cellular internalization.
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Properties of the xenon host can be changed by attaching different functional units to implement binding to specific targets.