Dr. Leif Schröder

phone +49 30 94793 121
🖂  lschroeder(at)
Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)

Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+49 30 94793 - 100
+49 30 94793 - 109 (Fax)
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The LEIPNIX Polarizer
Molecular Imaging
For the flexible production of hyperpolarized xenon with ca. 25 000-fold signal enhacement, we developped a new design that is mobile and can be used with variable gas composition (typically operated between 2% and 5% Xe fraction). Spin exchange optical pumping (SEOP) is performed with a line-narrowed laser diodes emitting at high power levels (>150 W) in cw mode. The polarization optics work with a single beam line, achiving a circular polarization degree of 99.99%. This ensures very efficient optical pumping of rubidium vapor.
The relative compact design of the LEIPNIX setup (Laser Enabled Increase of Polarization for Nuclei of Imprisoned Xenon) is optimized for continuous flow applications that allow for permanent production of solutions saturated with hyperpolarized xenon for encapsulation in molecular cages.
Ca. 1 liter/hour of 129Xe can be produced with a spin polarization of ~25%. The improved gas delivery system reduces the signal instability to less than 1%. We are constantly adapting and improving this setup to the needs of ultra-sensitive Xe NMR with various encoding schemes.

Current Team Members


Related Publication

Nature Protocols 12(10): 2050 (2017)

[doi: 10.1038/nprot.2017.081]

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