Dr. Leif Schröder
Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
13125 Berlin, Germany
+4930 94793 - 100
+4930 94793 - 109
phone +49 30 94793 121
Advanced Hyper-CEST Encoding
Chemical exchange saturation transfer (CEST) with hyperpolarized nuclei allows sensitive magnetic resonance detection of xenon biosensors. However, the classical approach is time consuming when the spectral dimension for the detection of various sensor signals should be conserved.
Our lab has developed the first fast Hyper-CEST encoding using gradients along one spatial dimension to "burn" the z-spectrum information into the projection profile of the sample containing the Hyper-CEST agent. Combined with the smashCEST approach from imaging, this method allows to encode a whole spectrum with a single Xe delivery.
Watch this [video] to time-resolved CEST spectroscopy at work.