Contact
Dr. Leif Schröder
phone +49 30 94793 121
🖂 lschroeder(at)fmp-berlin.de
phone +49 30 94793 121
🖂 lschroeder(at)fmp-berlin.de
Leibniz-
Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+49 30 94793 - 100
+49 30 94793 - 109 (Fax)
🖂 info(at)fmp-berlin.de
Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+49 30 94793 - 100
+49 30 94793 - 109 (Fax)
🖂 info(at)fmp-berlin.de
Intro | Members | Projects | Publications | Methods
Funding | News | Collaborations | Links
Funding | News | Collaborations | Links
DeLTA Spectroscopy
Molecular Imaging
Projects
Projects
Some CEST responses may overlap in the frequency dimension but still show different characteristics. The exchange dynamics provide additional parameters to distinguish between different micro-environments.
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Phospholipids with different fluidity are an example for significant differences in xenon exchange rates. Determining the CEST-induced depolarization time (t) by Laplace transform analysis (DeLTA) allows assignment of different exchange dynamics and can be combined with MRI to localize biomembranes of different fluidity.
Watch this [animation] to see how DeLTA works.
n
Phospholipids with different fluidity are an example for significant differences in xenon exchange rates. Determining the CEST-induced depolarization time (t) by Laplace transform analysis (DeLTA) allows assignment of different exchange dynamics and can be combined with MRI to localize biomembranes of different fluidity.
Watch this [animation] to see how DeLTA works.