Contact
Dr. Leif Schröder
phone +49 30 94793 121
Leibniz-Institut für
Molekulare
Pharmakologie im
Forschungsverbund
Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100
+4930 94793 - 109
phone +49 30 94793 121
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Xenon Biosensors
Molecular Imaging
Methods
NMR signals of the noble gas xenon are extremely sensitive to their molecular environment. In order to make this molecular specificty available for NMR contrast agents, xenon can be trapped in molecular cages that specifically bind to a certain analyte.
We functionalize cryptophan cages to enable, e.g., binding events of such xenon hosts to targets of biochemical relevance. Spacers between cage and targeting moiety are optimized in terms length and structure for sensitive NMR detection. They are also equipped with additional functional tags like fluorescent dyes.